Tibilon 2.5mg 28pcs Tablets

✔️ Uses of Tibilon 2.5

• Post menopausal osteoporosis
• Hormone replacement therapy

✔️ How does Tibilon 2.5 work?

It substitutes for the loss of estrogen production in postmenopausal women and treats menopausal symptoms such as hot flashes, night sweats, and vaginal problems. It also prevents bone loss following menopause.

✔️ Side Effects of Tibilon 2.5

Early treatment months may see vaginal bleeding/spotting. Other effects include headache, migraine, edema, dizziness, pruritus, weight gain, nausea, abdominal pain, rash, and depression.

✔️ Dosage & Administration of Tibilon 2.5

Daily intake of one Tibolone tablet (2.5 mg) swallowed with water or a drink, preferably at the same time daily. Symptom improvement typically occurs within weeks, with optimal results after three months.

Initiating Tibolone Tablet: Natural menopause-treated women should start Tibolone tablets at least 12 months post-last bleed. For surgical menopause, immediate treatment is recommended.

The transition from HRT: For sequential HRT, Tibolone starts a day post-prior regimen. For continuous-combined HRT, Tibolone can begin anytime.

• If within 12 hours, take the missed dose; otherwise, skip it and resume the regular schedule, though this may increase bleeding/spotting risk.

✔️ Indications:

Treatment of symptoms arising from natural or surgical menopause in postmenopausal women. Prevention of osteoporosis in women post-menopause at high fracture risk, unable to take alternative osteoporosis prevention medicines.

✔️ Pharmacology

Tibolone, a synthetic steroid, exhibits estrogenic, androgenic, and progestogenic properties. Rapidly metabolized after oral intake, Tibolone forms three compounds influencing its pharmacological effects. While two metabolites (3α−OH and 3β−OH) display estrogenic activity, a third (δ4-isomer) and the parent compound exhibit progestogenic and androgenic activities. Tibolone substitutes for lost estrogen post-menopause, alleviating menopausal symptoms and preventing bone loss. It affects vaginal, bone, and thermoregulatory centers (e.g., hot flushes) and improves vaginal dryness and atrophy. Tibolone also influences mood and libido.

✔️ Interaction

No reported Tibolone interactions exist, but consider potential interactions like enzyme-inducing compounds enhancing metabolism (e.g., barbiturates, carbamazepine). Tibolone may boost anticoagulant effects.

✔️ Contraindications

Pregnancy, lactation, hormone-dependent tumors, cardiovascular/cerebrovascular disorders, deep vein thrombosis, thromboembolic disorders, unknown vaginal bleeding cause, severe liver disorders.

✔️ Pregnancy & Lactation

Contraindicated during pregnancy/lactation; withdraw treatment if pregnancy occurs.

✔️ Precautions & Warnings

Caution in renal dysfunction, liver disease history, epilepsy, migraine, hypercholesterolemia, impaired carbohydrate metabolism, diabetes mellitus, and cholestatic jaundice.

Tibolone has low acute toxicity, but overdose may induce nausea, vomiting, and withdrawal bleeding in females, treated symptomatically if necessary.

✔️ Storage Conditions:

Store in a cool, dry, light-protected place, away from children's reach.